Last edited by Dugor
Thursday, July 30, 2020 | History

4 edition of Nitric oxide-stimulated ADP-ribosylation found in the catalog.

Nitric oxide-stimulated ADP-ribosylation

Stefanie Dimmeler

Nitric oxide-stimulated ADP-ribosylation

by Stefanie Dimmeler

  • 89 Want to read
  • 27 Currently reading

Published by Shaker in Aachen .
Written in English

    Subjects:
  • ADP-ribosylation.,
  • Nitric oxide -- Physiological effect.

  • Edition Notes

    StatementStefanie Dimmeler.
    SeriesReihe Biologie, Reihe Biologie (Aachen, Germany)
    Classifications
    LC ClassificationsQP625.A29 D56 1993
    The Physical Object
    Paginationiv, 111 p. :
    Number of Pages111
    ID Numbers
    Open LibraryOL1140047M
    ISBN 103861113554
    LC Control Number94108994
    OCLC/WorldCa29228793

    CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. In she obtained her doctorate in Konstanz on "Nitric oxide-stimulated ADP-ribosylation". From to Dimmeler was a postdoctoral fellow in the Biochemical and Experimental Division of the Department of Surgery the University of Cologne and then from to in the Medical Clinic, Department of Cardiology, the University of.

      Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase. Brüne B, Lapetina EG Arch Biochem Biophys, (2), 01 Jun Proteins by Nitric Oxide-Stimulated ADP Ribosylation Brian M. Sullivan, Stephen Wong, and Erin M. Schumanl Division of Biology California Institute of Technology Pasadena, California Abstract Nitric oxide has been shown to be an important neuronal signaling molecule that.

    Nitric oxide and nitric oxide-generating agents like 3-morpholinosydnonimine (SIN-1) stimulate the mono-ADP-ribosylation of a cytosolic, kDa protein in various tissues. Recently we demonstrated that the radical nitric oxide (NO) stimulates the auto-ADP-ribosylation of the glycolytic enzyme glyceraldehydephosphate dehydrogenase (GAPDH) resulting in enzyme inhibition. To further characterize this auto-ADP-ribosylation reaction we studied alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) for comparison.


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Nitric oxide-stimulated ADP-ribosylation by Stefanie Dimmeler Download PDF EPUB FB2

Nitric oxide-stimulated ADP-ribosylation (Reihe Biologie) Mass Market Paperback – January 1, by Stefanie Dimmeler (Author) › Visit Amazon's Stefanie Dimmeler Page. Find all the books, read about the author, and more. See search results for this author.

Are you an author. Author: Stefanie Dimmeler. In these studies we examined the effects of nitric oxide on the ADP-ribosylation of neutrophil proteins. Purified cytosol and plasma membrane were incubated with 32 P-NAD (5μM, 1μCi, 30 min) in the presence or absence of nitric oxide.

Nitric oxide induced the ADP-ribosylation of the 37 kD substrate present only in by: Nitric oxide stimulates ADP ribosylation of actin in association with the inhibition of actin polymerization in human neutrophils.

Robert Clancy. Division of Rheumatology, the Hospital for Joint Diseases, and. Department of Medicine, New York University Medical Center, New York, New by:   Nitric oxide generation in brain cytosolic fractions markedly enhances ADP-ribosylation of a single kDa protein.

By utilizing a biotinylated NAD and avidin affinity chromatography, we purified this protein. Partial amino acid sequencing establishes its identity as glyceraldehydephosphate dehydrogenase (GAPDH).

This is further confirmed by detection of GAPDH enzymatic activity in the Cited by: Nitric oxide stimulates ADP ribosylation of actin in association with the inhibition of actin polymerization in human neutrophils Article (PDF Available) in Journal of Leukocyte Biology 58(2)   1.

Introduction. In recent years, oxidative stress has been implicated in carcinogenesis, aging and a wide variety of human diseases and syndromes.3, 4 Poly(ADP-ribosylation), a posttranslational modification of nuclear proteins catalyzed by poly (ADP-ribose) polymerase (PARP), is known to be involved in oxidant-induced cellular response.

PARP activation results in consumption of. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. No. 2, June, pp. Properties of a Novel Nitric Oxide-Stimulated ADP-Ribosyltransferase Bernhard Brune1 and Eduardo G. Lapetina2 Division of Cell Biology, Burroughs Wellcome Company, Research Triangle Park, North Carolina Received Novem, and in revised form February 2, A novel.

Nitric oxide-stimulated modification of glyceraldehydephosphate dehydrogenase (GAPDH) by [adenylateP]NAD has been interpreted in recent reports as ADP-ribosylation.

Incubations of GAPDH with the NO-releasing agent sodium nitroprusside (SNP) and. Hippocampal proteins are also affected by NO. Modification of hippocampal synaptic proteins by nitric oxide-stimulated ADP ribosylation (Sullivan, Wong, & Schuman, ) and association of impaired cognitive performance in nNOS knockout mice with hippocampal protein derangements were reported (Kirchner et al., ).

Brüne B, Lapetina EG. Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase. Arch Biochem Biophys. Jun; (2)– Duman RS, Terwilliger RZ, Nestler EJ.

Endogenous ADP-ribosylation in brain: initial characterization of substrate proteins. J Neurochem. Dec; 57. Nitric oxide induced the ADP-ribosylation of the 37 kD substrate present only in cytosol.

Nitric oxide treatment of plasma membrane plus cytosol revealed the ADP-ribosylation of an additional 43 kD protein. This 43 kD substrate was identified as actin by both phalloidin precipitation and immunoblot (2-D) gel using specific anti-actin antibodies.

Treatment of isolated rod outer segments with the nitric oxide donor sodium nitroprosside demonstrated that a G protein can be a target for nitric oxide stimulated ADP-ribosylation (30,31) supporting our hypothesis that nitric oxide is an endogenous regulation of G pro- tein function through the stimulation of endogenous ADP-ribosyltransferases.

Modification of hippocampal synaptic proteins by nitric oxide-stimulated ADP ribosylation. B M Sullivan, S Wong, and E M Schuman; Division of Biology, California Institute of Technology, PasadenaUSA. Abstract. Nitric oxide has been shown to be an important neuronal signaling molecule that participates in both behavioral and synaptic.

Nitric oxide stimulates auto-ADP-ribosylationof glyceraldehydephosphate dehydrogenase ADP-ribosylation is enhanced by NO,and while this work was in preparation, Kots et al. (16) observed that SNP stimulates ADP-ribosylation ofGAPDHin humanerythro-cytes. Nitric oxide-induced S-nitrosylation of glyceraldehydephosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

J Biol Chem. Dec 15; (35)– McDonald LJ, Moss J. Stimulation by nitric oxide of an NAD linkage to glyceraldehydephosphate dehydrogenase. The present study examines the possible involvement of nitric oxide (NO)-stimulated endogenous ADP-ribosylation in long-term potentiation (LTP).

LTP was induced in hippocampal slices by stimulation of Schaffer collateral inputs to the CA1 pyramidal neurons. Proc. Natl. Acad. Sci. USA Vol. 90, pp.July Biochemnstry Stimulationbynitric oxide ofanNADlinkage to glyceraldehyde phosphatedehydrogenase (ADP-ribosylation/sodium nitroprusside/mercury) LEEJ.

MCDONALD*ANDJOELMOSS Laboratory ofCeliular Metabolism, National Heart, Lung, and Blood Institute, National Institutes ofHealth, Bethesda, MD Nitric oxide-stimulated modification of glyceraldehydephosphate dehydrogenase (GAPDH) by [adenylateP]NAD has been interpreted in recent reports as ADP-ribosylation.

Incubations of GAPDH with the NO-releasing agent sodium nitroprusside (SNP) and NAD resulted, however, in essentially equal incorporation of radiolabel from the adenine, phosphate, and nicotinamide moieties to the extent of. Alterations in inotropy, nitric oxide and cyclic GMP synthesis, protein phosphorylation and ADP-ribosylation in the endotoxin-treated rat myocardium and cardiomyocytes.

Molecular and Cellular Biochemistry(1), DOI: /BF   Brüne B, Lapetina EG. Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase. Arch Biochem Biophys. Jun; (2)– Dimmeler S, Lottspeich F, Brüne B.

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehydephosphate dehydrogenase. J Biol Chem. Aug 25; (24)–.

Modification of hippocampal synaptic proteins by nitric oxide- stimulated ADP Ribosylation Article (PDF Available) in Learning & Memory 3(5) January .In chemistry, a NONOate is a compound having the chemical formula R 1 R 2 N−(NO −)−N=O, where R 1 and R 2 are alkyl groups.

One example for this is 1,1-diethylhydroxynitrosohydrazine, or diethylamine dinitric compounds are unusual in having three sequential nitrogen atoms: an amine functional group, a bridging NO − group, and a terminal nitrosyl group.Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse marophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound.